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Why take Paxlovid®

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A COVID-19 infection can still become life threatening, especially if you have one or more risk factors for severe illness.

PAXLOVID can help prevent your mild-to-moderate COVID from getting worse if you have a risk factor for severe illness.
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Even if it's mild now, you may not want to risk COVID turning severe

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But an oral prescription medication like PAXLOVID could help

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Even if it starts out mild to moderate, many adults are still at increased risk for getting very sick with a COVID infection. PAXLOVID is an oral prescription medication specifically designed to stop the virus from multiplying and reduces the amount of it in your body.
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Know the difference

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Mild-to-moderate COVID

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  • Symptoms (such as fever, cough, sore throat, and more) that generally can be treated at home
  • These symptoms usually occur within the first few days of illness
  • Many people recover without needing special treatment, but in some people COVID becomes severe, often days into their symptoms. This is more likely if you have a high-risk factor
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Severe COVID

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  • Progressed to the point of being characterized as "very sick" and requiring hospitalization
  • Ventilator may be needed for enough oxygen
  • Could result in death
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Click here to see a more comprehensive list of COVID-19 symptoms
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PAXLOVID Clinical Trial Results

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A total of 2113 people from around the world participated in the PAXLOVID clinical trial.

All people who participated:

  • Tested positive for COVID
  • Were unvaccinated*
  • Had mild-to-moderate symptoms for 5 days or fewer
  • Had certain high-risk factors for progression to severe COVID
  • Were at least 18 years old


The study looked at whether PAXLOVID helped prevent hospitalization or death when compared to placebo.

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PAXLOVID reduced the risk of COVID‑related hospitalization or death by 86%*

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In a clinical trial vs placebo, 9 out of 977 people who started treatment with PAXLOVID within 5 days of their first COVID symptoms were hospitalized and none died. For those who took a placebo, 64 out of 989 were hospitalized and 12 died (from any cause).
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Studied with real-world people in mind

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The study group included:

  • People from different races and ethnicities
  • A near equal number of male and female participants
  • People as young as 18 and as old as 88


Everyone studied had at least one risk factor for progression to severe COVID. The most common risk factors among study participants included†:

  • A body mass index (BMI) of more than 25
  • Current cigarette smoking
  • Hypertension (high blood pressure)


Additionally, 61% of people in the study had 2 or more high-risk factors.

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*The approved use of PAXLOVID isn’t limited to unvaccinated people, but all people who participated in the clinical trial were unvaccinated.

†Participants all had at least one of these high-risk factors: diabetes, overweight (BMI >25), chronic lung disease (including asthma), chronic kidney disease, current smoker, a disease or treatment that causes a weakened immune system, heart disease, high blood pressure, sickle cell disease, neurodevelopmental disorders, active cancer, medically related technological dependence, or were 60 years of age and older. Based on the latest guidance, some of this high-risk inclusion criteria may differ from the CDC’s list of high-risk factors (eg, the CDC defines high risk as 50+).
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Did you know PAXLOVID can be taken with certain over‑the‑counter cold & flu products?

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Over-the-counter medications may help with COVID-19 symptoms such as fever or cough. However, certain medications should not be taken with PAXLOVID. Talk to your healthcare provider who can tell you if it's safe to take PAXLOVID with other medicines. Don't start taking a new medicine without talking with your healthcare provider.
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It’s important to understand the possible risks and side effects before taking PAXLOVID

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PAXLOVID isn't right for everyone. Before you start treatment, take a few moments to learn about potential safety issues and side effects to discuss with your healthcare professional.
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Learn more
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Safety, Side Effects & Drug Interactions

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Who Can Take PAXLOVID

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How to Get PAXLOVID

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