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Test-to-Treat* can help you get tested for COVID-19 and, if appropriate, receive treatment all in the same location.

*This link will take you to a website that is owned and operated by HHS. Pfizer is not responsible for the content or services of this site.
Find Locations1-800-232-0233 (TTY 888-720-7489)

Test-to-Treat* can help you get tested for COVID-19 and, if appropriate, receive treatment all in the same location.

*These links will take you to a website that is owned and operated by HHS. Pfizer is not responsible for the content or services of this site.
Find Locations1-800-232-0233 (TTY 888-720-7489)
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Now Authorized for Emergency Use

PAXLOVID has not been approved, but has been authorized for emergency use by FDA under an EUA, for the treatment of mild-to-moderate COVID-19 in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death.


The emergency use of PAXLOVID is only authorized for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of drugs and biological products during the COVID-19 pandemic under Section 564(b)(1) of the Act, 21 U.S.C. § 360bbb-3(b)(1), unless the declaration is terminated or authorization revoked sooner.

Fact Sheet for Patients, Parents, and Caregivers

CDC Update: On December 6, 2022, the CDC changed age-related guidance for those at high risk for progression to severe COVID-19 from 65+ to 50+. In addition, updates were made to the list of underlying medical conditions, as reflected in the "Who Can Take PAXLOVID" section below.

Product Expiration Date

The product expiration date is stated on the product packaging, both on the carton and on the individual blister cards.

As of September 6, 2022, the U.S. Food and Drug Administration (FDA) approved a shelf-life extension for PAXLOVID from 12 months to 18 months. If you have a PAXLOVID prescription with an expiration date listed on the left column of the chart below, please see the right column to find the extended expiration date.

Labeled Expiration Date

Extended Expiration Date

July 2022

January 2023

August 2022 

February 2023

November 2022 

May 2023

December 2022 

June 2023

January 2023

July 2023

February 2023 

August 2023

March 2023

September 2023

April 2023

October 2023

May 2023

November 2023
COVID​​​​​​​About COVID-19

COVID-19 is caused by a virus called a coronavirus. You can get COVID-19 through close contact with another person who has the virus.


COVID-19 illnesses have ranged from very mild to severe, including illness resulting in death. While information so far suggests that most COVID-19 illness is mild, serious illness can happen and may cause some of your other medical conditions to become worse.

Older people and people of all ages with severe, long-lasting (chronic) medical conditions like heart disease, lung disease, and diabetes, for example, seem to be at higher risk of being hospitalized for COVID-19.

You can find the full list of potential COVID-19 symptoms from the CDC here.

Information Icon​​​​​​​About PAXLOVID 

PAXLOVID is an investigational medicine used to treat mild-to-moderate COVID-19 in adults and children [12 years of age and older weighing at least 88 pounds (40 kg)] with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death. 


PAXLOVID is investigational because it is still being studied. There is limited information about the safety and effectiveness of using PAXLOVID to treat people with mild-to-moderate COVID-19. 

​​​​​​​Who can take PAXLOVID?

The FDA has authorized the emergency use of PAXLOVID for the treatment of mild-to-moderate COVID-19 in adults and children [12 years of age and older weighing at least 88 pounds (40 kg)] with a positive test for the virus that causes COVID-19, and who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA. 


If you test positive for COVID-19, talk to your healthcare provider as soon as possible. Your healthcare provider can tell you about your treatment options and if PAXLOVID is appropriate for you.

Who is at high risk for severe COVID-19?

People of all ages or groups can be infected with COVID-19. Some people are more likely than others to get very sick from COVID-19, which can lead to hospitalization or death, even when symptoms start off as mild.


Some people are at increased risk of getting very sick or dying from COVID-19 because of where they live or work, or because they can't get health care. This includes many people from racial and ethnic minority groups and people with disabilities.

In addition, having one or more of the following factors puts you at high risk of getting severe COVID-19*:

  • Age 50 years or older
  • Cancer
  • Chronic kidney disease
  • Chronic liver disease
  • Chronic lung disease (including moderate-to-severe asthma, bronchiectasis, bronchopulmonary dysplasia, chronic obstructive pulmonary disease [including emphysema and chronic bronchitis], interstitial lung disease, pulmonary embolism, pulmonary hypertension)
  • Cystic fibrosis
  • Dementia or other neurological conditions
  • Diabetes (Type 1 or Type 2)
  • Disabilities (including attention-deficit/hyperactivity disorder [ADHD], cerebral palsy, birth defects, intellectual and developmental disabilities, learning disabilities, spinal cord injuries, Down syndrome)
  • Heart conditions
  • HIV infection
  • Immunocompromised condition or weakened immune system
  • Mental health conditions (including mood disorders, schizophrenia spectrum disorders, and depression)
  • Overweight or having obesity
  • Physical inactivity
  • Pregnant or recently pregnant (for at least 42 days following end of pregnancy)
  • Sickle cell disease or thalassemia
  • Smoking, current or former
  • Solid organ or blood stem cell transplant
  • Stroke or cerebrovascular disease
  • Substance use disorders (such as alcohol, opioid, or cocaine use disorder)
  • Tuberculosis


*This list does not include all possible conditions that may put you at high risk of severe illness from COVID-19. If you have questions about a condition not included on this list, talk to your healthcare provider. Visit the CDC website for the latest information and the full list of high risk factors: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html.†

†This link will take you to a website that is owned and operated by the CDC. Pfizer is not responsible for the content or services of this site.
More InformationHow to Take

Learn how and when to take
​​​​​​​ this medicine. 

 Learn How Possible Side Effects

Learn about important
​​​​​​​possible side effects. 

 Learn More Frequently Asked Questions

Want to learn more? 

 Explore ​​​​​​​Answers
How to verify your tablets are authentic

PAXLOVID must be prescribed by a licensed healthcare provider and supplied by a government-approved pharmacy or medical facility.

Authentic PAXLOVID, from Pfizer Inc., will include the Pfizer name on the label and will be packaged in 5 aluminum push-through blister cards. Individual doses are not for sale. PAXLOVID will be packaged in a rectangular carton. The carton has a colorless, glossy coating that contains a repeated pattern of the Pfizer name and logo all over, and these repeating features are seen in a contrasting matte finish.

PAXLOVID consists of tablets for a 5-day oral treatment regimen, with morning and evening doses.

​​​​​​​NOTE: If you are a patient with moderate kidney disease, you may receive a carton with daily blister cards that have been altered to ensure you receive the correct dose.

To help determine whether the tablets are authentic, look for specific text on each side of the tablets

Tablet

Text

nirmatrelvir 

Front: 3CL | Back: PFE

ritonavir, manufactured by AbbVie

Front: iconNK | Back: No text

ritonavir, manufactured by
Hetero

Front: H | Back: R9

Pfizer is committed to patient safety and ensuring that people have accurate information about the investigational drug PAXLOVID, including how it is accessed and administered. We are actively monitoring for fraudulent offers of illegitimate PAXLOVID to protect patients from products that might be dangerous and lead to serious and life-threatening harm.

If you suspect the product you have received may be counterfeit, contact us at 1-800-438-1985 or visit  www.pfizersafetyreporting.com.

Not actual size
For more
information

Contact One of the Following Groups

For Medical Information visit www.pfizermedicalinformation.com or call 1-800-438-1985

For General Product Inquiries call 1‑877‑C19PACK (1-877-219-7225)

This site is intended only for U.S. residents. The products discussed in this site may have different product labeling in different countries.
The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider.

 Copyright © 2023 Pfizer Inc. All rights reserved. PP-PAX-USA-0442

AUTHORIZED USE

​​​​​​The FDA has authorized the emergency use of PAXLOVID, an investigational medicine, for the treatment of mild-to-moderate COVID-19 in adults and children (12 years of age and older weighing at least 88 pounds [40 kg]) with a positive test for the virus that causes COVID-19, and who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA.

PAXLOVID is investigational because it is still being studied. There is limited information about the safety and effectiveness of using PAXLOVID to treat people with mild-to-moderate COVID-19.

IMPORTANT SAFETY INFORMATION

Expand​​​​​​Before taking PAXLOVID, tell your healthcare provider if you:
  • Have any allergies
  • Have liver or kidney disease 
  • Are pregnant or plan to become pregnant
  • Are breastfeeding a child
  • Have any serious illnesses

Some medicines may interact with PAXLOVID and may cause serious side effects.
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • Your healthcare provider can tell you if it is safe to take PAXLOVID with other medicines.
  • You can ask your healthcare provider or pharmacist for a list of medicines that interact with PAXLOVID.
  • Do not start taking a new medicine without telling your healthcare provider.
     
Tell your healthcare provider if you are taking combined hormonal contraceptive. ​​​​​​PAXLOVID may affect how your birth control pills work. Females who are able to become pregnant should use another effective alternative form of contraception or an additional barrier method of contraception. Talk to your healthcare provider if you have any questions about contraceptive methods that might be right for you.     
Tell your healthcare provider if you are taking combined hormonal contraceptive. ​​​​​​PAXLOVID may affect how your birth control pills work. Females who are able to become pregnant should use another effective alternative form of contraception or an additional barrier method of contraception. Talk to your healthcare provider if you have any questions about contraceptive methods that might be right for you.
 
​​​​​​HOW TO TAKE PAXLOVID
  • PAXLOVID consists of 2 medicines: nirmatrelvir and ritonavir. The 2 medicines are taken together 2 times each day for 5 days.
    • Nirmatrelvir is an oval, pink tablet. 
    • Ritonavir is a white or off-white tablet.
  • PAXLOVID is available in 2 Dose Packs. Your healthcare provider will prescribe the PAXLOVID Dose Pack that is right for you.
  • If you have kidney disease, your healthcare provider may prescribe a lower dose. Talk to your healthcare provider to make sure you receive the correct Dose Pack.
  • Do not remove your PAXLOVID tablets from the blister card before you are ready to take your dose.
  • Take your first dose of PAXLOVID in the Morning or Evening, depending on when you pick up your prescription, or as recommended by your healthcare provider.
  • Swallow the tablets whole. Do not chew, break, or crush the tablets.
  • Take PAXLOVID with or without food.  
  • Do not stop taking PAXLOVID without talking to your healthcare provider, even if you feel better.
  • If you miss a dose of PAXLOVID within 8 hours of the time it is usually taken, take it as soon as you remember. If you miss the dose by more than 8 hours, skip the missed dose and take the next dose at your regular time. Do not take morning and evening doses of PAXLOVID at the same time. 
  • If you take too much PAXLOVID, call your healthcare provider or go to the nearest hospital emergency room right away.​
  • If you are taking a ritonavir- or cobicistat-containing medicine to treat hepatitis C or Human Immunodeficiency Virus (HIV), you should continue to take your medicine as prescribed by your healthcare provider.

​​​​​​Talk to your healthcare provider if you do not feel better or if you feel worse after 5 days. ​​​​
Do not take PAXLOVID if:
  • You are allergic to nirmatrelvir, ritonavir, or any of the ingredients in PAXLOVID.
  • You are taking any of the following medicines:
    • alfuzosin
    • amiodarone
    • apalutamide
    • carbamazepine
    • colchicine
    • dihydroergotamine
    • dronedarone
    • eletriptan
    • eplerenone
    • ergotamine
    • finerenone
    • flecainide
    • flibanserin
    • ivabradine
    • lomitapide
    • lovastatin
    • lumacaftor/ivacaftor
    • lurasidone
    • methylergonovine
    • midazolam (oral)
    • naloxegol
    • phenobarbital
    • phenytoin
    • pimozide
    • primidone
    • propafenone
    • quinidine
    • ranolazine
    • rifampin
    • St. John’s Wort (hypericum perforatum)
    • sildenafil (Revatio®) for pulmonary arterial hypertension
    • silodosin
    • simvastatin
    • tolvaptan
    • triazolam
    • ubrogepant
    • voclosporin

Taking PAXLOVID with these medicines may cause serious or life-threatening side effects or affect how PAXLOVID works.These are not the only medicines that may cause serious side effects if taken with PAXLOVID. PAXLOVID may increase or decrease the levels of multiple other medicines. It is very important to tell your healthcare provider about all medicines you are taking because additional laboratory tests or changes in the dose of your other medicines may be necessary while you are taking PAXLOVID. Your healthcare provider may also tell you about specific symptoms to watch out for that may indicate that you need to stop or decrease the dose of some of your other medicines.
Possible side effects of PAXLOVID are:
  • Allergic Reactions. Allergic reactions, including severe allergic reactions (known as ‘anaphylaxis’), can happen in people taking PAXLOVID, even after only 1 dose. Stop taking PAXLOVID and call your healthcare provider right away if you get any of the following symptoms of an allergic reaction:
    • hives
    • trouble swallowing or breathing
    • swelling of the mouth, lips, or face
    • throat tightness
    • hoarseness
    • skin rash
  • Liver Problems. Tell your healthcare provider right away if you have any of these signs and symptoms of liver problems: loss of appetite, yellowing of your skin and the whites of eyes (jaundice), dark-colored urine, pale-colored stools and itchy skin, or stomach area (abdominal) pain.
  • Resistance to HIV Medicines. If you have untreated HIV infection, PAXLOVID may lead to some HIV medicines not working as well in the future.
  • Other possible side effects include:
    • altered sense of taste
    • diarrhea
    • high blood pressure
    • muscle aches
    • abdominal pain
    • nausea
    • feeling generally unwell
These are not all the possible side effects of PAXLOVID. Not many people have taken PAXLOVID. Serious and unexpected side effects may happen. PAXLOVID is still being studied, so it is possible that all of the risks are not known at this time.There is no experience treating pregnant women or breastfeeding mothers with PAXLOVID. For a mother and unborn baby, the benefit of taking PAXLOVID may be greater than the risk from the treatment. It is recommended that you use effective barrier contraception or do not have sexual activity while taking PAXLOVID. If you are pregnant or breastfeeding, discuss your options and specific situation with your healthcare provider.Contact your healthcare provider if you have any side effects that bother you or do not go away. Report side effects or problems with the appearance or packaging of PAXLOVID to FDA MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088, or you can report side effects to Pfizer Inc. at www.pfizersafetyreporting.com, by fax at 1-866-635-8337, or by calling 1-800-438-1985.Please see Fact Sheet for Healthcare Providers and Fact Sheet for Patients, Parents, and Caregivers.